Many people who live with Pemphigus report a direct relationship between increased stress and flares in disease activity.  In some people, stress clearly does affect the immune system and exacerbate autoimmune diseases.  Others seem to be unaffected by increased stress in this way.

If you believe stress is related to increased incidence of lesions, it is wise to address and resolve those stress issues. Obviously, many causes of stress are not a matter of choice, but the manner in which an individual deals with the various sources of stress can be modified. One of the most common and effective ways to help reduce stress is to openly and honestly discuss it with a spouse, friend, or therapist. Having someone in your corner helps.