Definitive statistics on the incidence and prevalence of pemphigus are not available, but estimates of the number of new cases diagnosed each year ranges from as high as 5 per one hundred thousand to as low as one per million, depending upon the type of pemphigus and the ethnicity of the affected population.

It is known to affect people across racial and cultural lines. However, there are certain groups of people (Eastern European Jews, people of Mediterranean, Northern India and Persian decent) who have a higher incidence of the disease.

Men and women are equally affected. Although the onset usually occurs in middle-aged and older adults, Pemphigus Vulgaris and Pemphigus Foliaceus also occur in young adults and children.